4/30/2023 0 Comments Unfolder dlbcl trial![]() ![]() After a median follow-up of 70 (0.03-117) months, patients assigned to chemotherapy and rituximab had increased 6-year event-free survival compared with those assigned to chemotherapy alone (74.0% vs 55.7% log-rank p60 months) events after CHEMO (61.4 to 96.1 months), including 4 in the very favorable subgroup, while all 8 late events (67.5 to 105.7 months) after R-CHEMO occurred in the less favorable subgroup only, and none in the very favorable subgroup. In the latest ESMO guidelines, consolidation radiother- apy for DLBCL patients is recommended for both elderly and intermediate- and high-risk young patients with bulky disease.6NCCN is less firm, and mainly restricts its recommendation to residual disease (partial remission or PET-positivity, Online Supplementary Table S1). Toxicity, incidence of adverse events and severe adverse events in the CHEMO and the R-CHEMO arms were not significantly different. R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) is standard care for aggressive B-cell lymphoma. ![]() Pediatric studies suggest that the biology. Between 05/2000 and 10/2003 a total of 823 patients were recruited of whom 396 were allocated to receive CHOP-21, 361 to CHOEP-21, 34 to MACOP-B, and 32 to PMitCEBO with or without rituximab. Request PDF Role of radiotherapy and dose-densification of R-CHOP in primary mediastinal B-cell lymphoma: A subgroup analysis of the unfolder trial of the German Lymphoma Alliance (GLA). Biologically, adult PMBCL has more similarities to Hodgkin Lymphoma (HL) than diffuse large B-cell lymphoma (DLBCL). ![]()
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4/30/2023 0 Comments Cut the rope magic box level 22![]() The game has amassed over a million downloads on several mobile operating systems due to its captivating narrative, appealing animation, and endearing main character. In mobile gaming, the original Cut The Rope has attracted a lot of attention. The game’s simple graphics are a drawback, but the engaging levels make up for it. One of the box’s walls is visible in the backdrop, as one might anticipate. The game’s graphic quality is just above average, which is not very significant for an arcade. All you have to do to cut the rope is tap the phone’s touchscreen with your fingertip. Currently doing videos on Cut The Rope: Magic, Angry Birds Rio and Mekorama. Only the touch screen may be used to play Cut the Rope. I make videos on gameplay and walkthrough of all the levels of different games. Mechanical Box (or simply Mechanical) is the seventeenth and final box in the original Cut the Rope game and is the seventh and final box in Season 3. Additionally, it is vital to picture where the candy will land if you cut one or more threads. ![]() He must consider his options carefully before acting in the final levels. The player has to cut the ropes, inflate the balls, then explode them. The game’s goal is to feed the candies to the green monster while obtaining as many golden stars as possible. Although the game’s aesthetics and soundtrack are not very inventive, it has an engaging plot and gameplay. It will get harder and harder for you to feed the green monster each time since the game has various levels and settings. You will need to provide him with this unique approach. Cut the Rope Magic Cut the Rope Time Travel Cut the Rope 2 Cut The Rope. A unique mechanism using ropes was developed to prevent him from accidentally biting off your hand while being fed. Watch how to get all three stars in Cardboard Box level 1-21 of Cut the Rope for. Level 10-01: To complete this stage, start by cutting the middle rope, wait for the two stars on the side to get picked up and then cut the two remaining ropes. To maintain him in a safe state, you’ll need to give him sweets. You open this package – it has a little green monster within, which is bizarre. You had a call at the door one day, and when you opened it, there was a strange package on the threshold. ![]() With 100 different levels, five transformations, and various final bosses, it's not hard to spend hours playing this delightful game.It’s pretty easy in this case. By pressing a button, you can transform Om Nom into different animals (a bird, fish, mouse, etc.), each of which has its own special skill.Ĭut the Rope: Magic is an outstanding puzzle game, just like the previous editions of the saga. This time, though, there's a new concept: magic. The gameplay follows the same line as in previous installments. The previous installments also had great graphics, but Magic sets the bar even higher, with a highly refined character design, incredibly smooth animations, and a fantastic use of color. The first thing that will draw you to Cut the Rope: Magic is without a doubt its beautiful graphics. On top of that, this game comes chock-full of novelties at the level of both gameplay and graphics. With over 700 million downloads across all platforms, its become one of the most widely played games on Android. The player can collect stars and use various equipment to move the candy. On top of that, this game comes chock-full of novelties at the level of both gameplay and graphics. please like the the new videos and keep up to date and subscribe my channel for instant updates for the new videos and keep up to date and subscribe my chann. Cut the Rope: Magic is the fifth installment of this popular franchise developed by Zeptolab. Cut the Rope gameplay is based on delivering the candy to Om Nom. ![]() Cut the Rope: Magic Mushroom Land - level 2-7 WalkthroughTwitter - https://twitter. Level 08-21: Stage strategy to be determined. ![]() With over 700 million downloads across all platforms, it's become one of the most widely played games on Android. Cut The Rope: Valentine Box Level 5-7 Walkthrough Over 100 million. Let the candy enter the bubble and then float the treat up for Om Nom to consume. Cut the Rope: Magic is the fifth installment of this popular franchise developed by Zeptolab. ![]() 4/29/2023 0 Comments Squier classic vibe![]() Get yourself slice of guitar history with decade-specific. As one of the UK's largest authorised Squier dealers, we have a huge amount of the best Squier Classic Vibe guitars available to try in-store. Squier Classic Vibe instruments are inspired by vintage Fender models of the 50s, 60s and 70s. If you are in the market for a Squier Classic Vibe guitar or bass, come to guitarguitar. Spanning all of the favourites including 50s Telecasters, 60s Strats, Jazz basses and many more, this interesting and best selling range delivers more performance per pound than perhaps any brand series by any brand. With vintage-inspired styles, finishes, hardware and detailing, Squier Classic Vibe guitars offer many viable options for the gigging and recording musician. Squier Classic Vibe 70s Precision Bass in Walnut with Maple Fretboard. These instruments display a level of value and professionalism far beyond their price tag. La serie más aclamada de la compañía se compone de reediciones de clásicos de los ♆0 y ♇0, con materiales de primera y una estética imponente. The Squier Classic Vibe series really shook up the market when it first appeared. Known for their incredible value for money, the Squier Classic Vibe series has an entry level price, but performs at a much higher level. ![]() Squier Classic Vibe is inspired by the incredible and iconic Fender guitars of it's golden era during the 50's, 60's and 70's. ![]() 4/29/2023 0 Comments Teenagent walkthru![]() ![]() The animation quality drops significantly during the few simple cutscenes that occur, but they are brief and uncommon. Every screen feels halfway between a storybook illustration and a Saturday morning cartoon, and the bouncy, versatile MIDI score does an excellent job of setting the mood, whatever the context. The characters are lively and fluidly animated, with their personalities coming through as much in the way they look and move as through dialogue (and often more so). There’s no word for the hand-drawn backgrounds but stunning their lush colors, painterly sensibilities and excellent compositions are on par with the best the era had to offer. Here Arivald’s narrative ends, and we join the fugitive Galador in a nearby graveyard as he tries to work out a plan: first, find the demon who swindled him second, get his own body back and finally, free the unfortunate prince from the clutches of Hell.įor the first hour or so, the game manages to glide along almost entirely on charm. The panicked protagonist, meanwhile, fled the field of honor as the duel began-in the process dishonoring his “father,” the king, who promptly disowned him and named him an enemy of the state. This prince, it turns out, had been the demon’s target all along, but he’d never have offered his soul voluntarily this trick provided a loophole through which His Highness might be spirited away to the infernal regions without technically breaking Lucifer’s rules. He explains that the titular Galador was a lazy young man who encountered a demon and was offered a simple trade: in exchange for his soul, he could have “a life of adventure and the title of prince.” The lad happily made the bargain, but the demon had something unexpected in mind: Galador found himself in the body of a handsome, brave and very much currently alive prince-who at that very moment was entering a duel to the death. The game begins with a close-up of Arivald, the self-proclaimed greatest wizard in the world, who fills us in on the backstory needed to understand what comes next. If nothing else, Galador provides an effective counterbalance to the overly rosy view of the 1990s that’s sometimes prevalent in adventure circles: it was a Golden Age, to be sure, but there was more electroplating in the mix than we often remember. Its story is a flimsy excuse to connect underdeveloped set pieces its characters, for all that their visual designs ooze personality, mostly appear for a single puzzle before vanishing entirely and its puzzles require such mind-boggling leaps of logic that I almost hesitate to use the term, implying as it does a clear sense of cause and effect imposed by comprehensible rules and boundaries. Like that earlier adventure, Galador takes its aesthetic cues from its much-beloved contemporaries-with Discworld II, The Curse of Monkey Island, and the later King’s Quest adventures standing out as obvious influences-but again like Teenagent, it fails utterly to grasp what made those games worth playing. Galador was developed by Metropolis Software as their follow-up to 1994’s abysmal Teenagent, and maybe the worst thing I can say about it is that it shows. Well, I’ve spent fifteen hours with the thing, and I don’t have the energy left to beat around the bush: No. At last, English speakers could finally answer the question themselves: does Galador play as good as it looks? ![]() ScummVM added support for Galador in 2020, with a community-produced fan translation following later that year, but even then it took until late 2021 for the game to reappear for sale via digital download. Well-regarded in its native Poland, it nonetheless spent two decades without any sort of English release, meaning screenshots of its gorgeous hand-drawn backgrounds and colorful cartoon characters were all many of us had to go on. ![]() For years, Galador: The Prince and the Coward has been an object of some curiosity among adventure completionists in the English-speaking world. ![]() 4/29/2023 0 Comments Yes mail for gmail![]() the exact address of Google’s mail is but you can access it by simply typing or (with or without you can find Gmail contacts in the menu.If you were already logged in to Gmail in your browser, you do not need to identify yourself by providing your email address and password. In this case, check that it is the correct account and if not, you must first log out of Gmail .type your Gmail password then click Next.open the page if asked, type the email address of your Gmail account, which ends with then click Next.To access your Gmail account in a web browser: ![]() See also: what is the max attachment size for Gmail? Gmail login box on a web browser This solution is very simple and works just as well on a computer (Windows, Mac, Linux) as on a smartphone or tablet (without the need to install an application). The downside is that you may need to log in regularly (providing your email and password). See also: tutorial to find your Gmail password Access Gmail in a web browser ( portal) Note: On iOS (iPhone and iPad), you may see the “Try Gmailify” option. If so, turn on Gmailify to take advantage of Gmail features like spam protection and using categories, even if your email address isn’t Gmail. ![]() See also: add a signature with image in Gmail In both cases, you will then arrive on your Gmail inbox. follow the on-screen instructions to add your account.choose the type of account to add (Gmail or Google account).in the top right, tap your profile picture.Otherwise, follow the instructions to add your account: check that you are viewing the correct Google account, if you have more than one set up on your phone. If necessary, switch to your account by clicking on the profile icon at the top right.If you have already set up your Google account (with your Gmail email address), then: On a mobile or tablet running on Android, the Gmail app is already installed. On iPhone or iPad, you can install the Gmail app from the App Store, then set up your account. Other questions… Connect to your Gmail account using the application on your phone or tablet.Consult your Gmail box in an email software on a computer (Outlook, Thunderbird, Apple Mail, etc.).Access Gmail in a web browser ( portal). ![]() 4/29/2023 0 Comments Smashing four aimbot![]() ![]() ![]() All of which will make the online gameplay of Smashing Four a lot more exciting. Share cards with your clan mates, communicate in group chats, and have fun challenging your clanmates in friendly battles. Simply join an existing clan or create your own clan to start having fun with Smashing Four. Enjoy interesting Clan gameplayįor those of you who are interested, you can also explore the awesome Clan gameplay in Smashing Four. Explore the interesting environments with awesome setups which will allow you to have fun with Smashing Four in different experiences. To make the game more interesting, Android gamers can now learn to work with 10 game-changing Arenas, each offering its own unique settings and addictive in-game elements. Interesting Arenas with amazing environments Create the ultimate roster, which will allow you to further advance in Smashing Four. Explore the awesome powers and abilities from your different heroes to learn ways that you can combine their powers. Build your perfect team with interesting strategiesĪnd for those of you who are interested, you can now build your perfect team in Smashing Four and unlock interesting in-game strategies. ![]() Get all available and always expect new arrivals in Smashing Four. Feel free to collect multiple hero cards, each having their own unique abilities and attributes. Here in the game, there will be multiple heroes with interesting abilities, which you can make uses of and allow them to further enjoy their in-game battles. Interesting heroes with awesome abilities Complete your in-game challenges and get ranked up so you can enjoy even more interesting battles with skilled players. Duel your opponents in many challenging arenas, win battles to earn special rewards, and smash your opponents in many exciting arena fights. Have fun joining the awesome online matchups in Smashing Four where you can compete with players from all over the world. Compete with players from all over the world All of which will make sure that you can enjoy Smashing Four to the fullest. Enjoy the exciting PvP gameplay, have fun with real-time battles, explore the turn-based matchups, and experience unique card-collectible strategy. Exciting smashy battles with unique elementsįor those of you who are interested, you can now make uses of the available gameplay of Smashing Four and experience its amazing elements. All it takes is for you to aim your smashy heroes, pull them back to the opposite direction, and release your awesome shots to effectively fire the hero toward the selected direction. To start with, Android gamers will have their chances to enjoy the exciting gameplay of Smashing Four, thanks to its simple and intuitive touch controls, along with interesting gameplay of smashy action. Here are all the exciting features that the game has to offer: Simple and intuitive touch controls And most importantly, the exciting online game modes will allow gamers to have fun with actual gamers in exciting real-time matchups whenever they are ready. Build your ultimate rooster with amazing heroes and characters. Unlock new heroes with amazing abilities and make the most of them to effectively take down your opponents. Take on multiple in-game levels and engage yourself in many hilarious matchups. Tackle the enemies and advance yourself in the awesome mobile adventures. Fight in hilarious smashy gameplay simply by pulling and releasing your heroes to the selected directions. Smashing Four is a classic strategy gameplay where Android gamers can take their epic heroes through many addictive and exciting battles against the nasty enemies. All of which will allow gamers to enjoy the exciting game to the fullest.įind out more about this awesome mobile game from Geewa with our in-depth review. Have fun in multiple in-game levels, or challenge online gamers from all over the world. Win battles, gain trophies, collect rewards & cards, and experience the awesome gameplay of strategy, as you comfortably guide the smashy heroes through the arenas. Make uses of the unique pool physics to effectively take down the opponents. Experience realistic in-game physics and hilarious gameplay, where you can easily send your smashy heroes flying toward the enemies. Have fun entering the awesome Arena and get yourself ready for the fierce in-game battles against players from all over the world. Smashy fans will now have their chances to engage in yet another great mobile gameplay with Smashing Four. Enjoy the unlocked version of the game on our website.Interesting Arenas with amazing environments.Build your perfect team with interesting strategies.Interesting heroes with awesome abilities.Compete with players from all over the world.Exciting smashy battles with unique elements. ![]() |
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